VSL3 Is Effective Adjunctive Therapy for Mild to Moderately Active Ulcerative Colitis

A Meta-analysis using VLS3

VSL3 for Ulcerative Colitis

BACKGROUND:

VSL3 is a probiotic mix preparation reported to be effective in the treatment of mild to moderately active ulcerative colitis. We aimed to perform a systematic review of the literature and a meta-analysis of studies on its efficacy.

METHODS:

The searched databases included PubMed, Scopus, and ScienceDirect. The Mantel-Haenszel method was used to pool the effect- ize across studies, and the odds ratios (ORs) and 95% confidence intervals (CIs) of experiencing a specific outcome were calculated.

RESULTS:

Five studies with 441 patients were identified. The pooled remission rate was 49.4% (95% CI, 42.7-56.1). Only 3 low risk of bias studies with 319 patients met the inclusion criteria for further analysis. A total of 162 patients received 3.6 × 10 CFU/d VSL3, and 157 patients received placebo. A total of 95% of patients received concomitant therapies with 5-ASA and/or immunomodulators. The Ulcerative Colitis Disease Activity Index was used to define response and remission. A >50% decrease in the Ulcerative Colitis Disease Activity Index was achieved in 44.6% of the VSL3-treated patients versus 25.1% of the patients given placebo (P = 0008; OR, 2.793; 95% CI, 1.375-5.676; number needed to treat = 4-5). The response rate was 53.4% in VSL3-treated patients versus 29.3% in patients given placebo (P < 0001; OR, 3.03; 95% CI, 1.89-4.83; number needed to treat = 3-4). The remission rate was 43.8% in VSL3-treated patients versus 24.8% in patients given placebo (P = 0007; OR, 2.4; 95% CI, 1.48-3.88; number needed to treat = 4-5). No serious side effects were reported.

CONCLUSIONS:

VSL3, when added to conventional therapy at a daily dose of 3.6 × 10 CFU/d, is safe and more effective than conventional therapy alone in achieving higher response and remission rates in mild to moderately active ulcerative colitis.

CK HERE to view full-text of this research

VSL3 Is Effective Adjunctive Therapy for Mild to Moderately Active Ulcerative Colitis
Rate this post
Gut Bacteria and IBS
IBS And Gut Bacteria
What is the relationship of stress to IBS
What Is The Relationship Between IBS And Stress
Irritable Bowel Syndrome, Gut Microbiota and Probiotics
Introduction to Irritable bowel syndrome (IBS)
Group of Carbohydrates May Be Hard To Digest
Group of Carbohydrates May Be Hard To Digest
Food Components and Irritable Bowel Syndrome
Food Components and Irritable Bowel Syndrome
How to Follow The Low-FODMAP Diet
How to Follow The Low-FODMAP Diet
Probiotics for IBS - Irritable Bowel Syndrome
Probiotics for IBS – Irritable Bowel Syndrome
Yoga for IBS Relief
Yoga for IBS Relief
Famous People With IBS - Irritable Bowel Syndrome
Famous People With IBS – Irritable Bowel Syndrome
How To Solve Irritable Bowel Syndrome
How To Solve Irritable Bowel Syndrome
IBS – Irritable Bowel Syndrome
Complementary Health Practices for Irritable Bowel Syndrome Treatment
Valeant to Acquire Specialty Salix Pharma
Valeant to Acquire Specialty Salix Pharma
Food Components and Irritable Bowel Syndrome
Food Components and Irritable Bowel Syndrome
Probiotics for IBS - Irritable Bowel Syndrome
Probiotics for IBS – Irritable Bowel Syndrome
IBD patients are misdiagnosed with irritable bowel syndrome IBS
IBD patients are misdiagnosed with irritable bowel syndrome IBS
Probiotics are beneficial bacteria
Probiotics are beneficial bacteria
Breast Milk Studies May Lead to Better Probiotics Baby Formula
Breast Milk Studies May Lead to Better Probiotics Baby Formula
Probiotic Supplements May Contain Unlabeled Traces of Gluten
Some Probiotic Supplements May Contain Unlabeled Traces of Gluten
How Probiotics May Help Ease Social Anxiety
How probiotics may help ease social anxiety
Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion
Probiotics for prevention of radiation-induced diarrhea: A meta-analysis of randomized controlled trials
Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms
Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing